ITGA4

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/ITGA4 latin yazuında])
ITGA4
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген Интегрин альфа-4[d][1]
Молекулярная функция связывание с белками плазмы[d][2][3][4][…], protein antigen binding[d][5], связывание с ионом металла[d][5], antigen binding[d][5], fibronectin binding[d][5], cell adhesion molecule binding[d][6][7][5], coreceptor activity[d][8], C-X3-C chemokine binding[d][8] һәм protein heterodimerization activity[d][9]
Күзәнәк компоненты экзосома[d][10][11][12], часть мембраны[d][5], мембрана[d][10][13], Фокальные контакты[d][14], поверхность клетки[d][5][7][15][…], integrin alpha4-beta7 complex[d][7][15], integrin complex[d][5], күзәнәк мембраны[d][5][5][6], Фокальные контакты[d][16], мембрана[d][5][17], Конус роста[d][5], neuronal cell body[d][5], экзосома[d][5][18][19] һәм protein-containing complex[d][9]
Биологический процесс endodermal cell differentiation[d][20], B cell differentiation[d][21], positive regulation of T cell migration[d][5], extracellular matrix organization[d][5], heterotypic cell-cell adhesion[d][22], substrate adhesion-dependent cell spreading[d][7], cellular response to cytokine stimulus[d][5], cell-matrix adhesion involved in ameboidal cell migration[d][7], cell-matrix adhesion[d][7][15], leukocyte tethering or rolling[d][15], Диапедез[d][5], regulation of immune response[d][5], integrin-mediated signaling pathway[d][5], leukocyte migration[d][5], positive regulation of leukocyte tethering or rolling[d][5], positive regulation of leukocyte cell-cell adhesion[d][5], positive regulation of leukocyte migration[d][5], import into cell[d][5], leukocyte cell-cell adhesion[d][21], negative regulation of protein homodimerization activity[d][6], clathrin-dependent extracellular exosome endocytosis[d][5], Агрегация клеток[d][5][5], receptor clustering[d][7], cell-cell adhesion mediated by integrin[d][23], heterotypic cell-cell adhesion[d][15][23], axonogenesis involved in innervation[d][5], cell-cell adhesion in response to extracellular stimulus[d][23], cellular response to amyloid-beta[d][23], positive regulation of vascular endothelial cell proliferation[d][24], neuron projection extension[d][5] һәм positive regulation of endothelial cell apoptotic process[d][24]
Изображение Gene Atlas

ITGA4 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[25][26]

Искәрмәләр[үзгәртү | вики-текстны үзгәртү]

  1. 1,0 1,1 UniProt
  2. Y Takada Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.272.13.8447PMID:9079671
  3. Takada Y., Noda M. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor // J. Cell Sci.The Company of Biologists, 2004. — ISSN 0021-9533; 1477-9137doi:10.1242/JCS.01423PMID:15466886
  4. Ring C., Ginsberg M. H., Haling J. et al. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 2010. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.1012316108PMID:21173240
  5. 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 5,10 5,11 5,12 5,13 5,14 5,15 5,16 5,17 5,18 5,19 5,20 5,21 5,22 5,23 5,24 5,25 5,26 5,27 5,28 5,29 GOA
  6. 6,0 6,1 6,2 Breau M. A., Lutz P. G. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells // BloodAmerican Society of Hematology, Elsevier BV, 2003. — ISSN 0006-4971; 1528-0020doi:10.1182/BLOOD-2002-11-3462PMID:12869515
  7. 7,0 7,1 7,2 7,3 7,4 7,5 7,6 Xu C. Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇ // J. Cell Sci.The Company of Biologists, 2013. — ISSN 0021-9533; 1477-9137doi:10.1242/JCS.134528PMID:23986478
  8. 8,0 8,1 Takada Y. Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1 // J. Immunol.Baltimore: 2012. — ISSN 0022-1767; 1550-6606doi:10.4049/JIMMUNOL.1200889PMID:23125415
  9. 9,0 9,1 Bernabeu C. Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation // Eur. J. Immunol.Wiley-Blackwell, 1994. — ISSN 0014-2980; 1521-4141doi:10.1002/EJI.1830240107PMID:8020569
  10. 10,0 10,1 GOA
  11. Möbius W., Stoorvogel W. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M207550200PMID:12519789
  12. Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell BiologyWiley, 2010. — ISSN 0818-9641; 1440-1711doi:10.1038/ICB.2010.64PMID:20458337
  13. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  14. Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol.NPG, 2011. — ISSN 1465-7392; 1476-4679doi:10.1038/NCB2216PMID:21423176
  15. 15,0 15,1 15,2 15,3 15,4 Lalor P., Adams D. CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow // American Journal of Physiology: Gastrointestinal and Liver PhysiologyAmerican Physiological Society, 2008. — ISSN 0193-1857; 1522-1547doi:10.1152/AJPGI.00266.2007PMID:18308860
  16. Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol.NPG, 2011. — ISSN 1465-7392; 1476-4679doi:10.1038/NCB2216PMID:21423176
  17. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  18. Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell BiologyWiley, 2010. — ISSN 0818-9641; 1440-1711doi:10.1038/ICB.2010.64PMID:20458337
  19. Möbius W., Stoorvogel W. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M207550200PMID:12519789
  20. Brafman D. A., C Phung, N Kumar et al. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions // Cell Death & DifferentiationNPG, 2013. — ISSN 1350-9047; 1476-5403doi:10.1038/CDD.2012.138PMID:23154389
  21. 21,0 21,1 Ryan D. H., Nuccie B. L., Abboud C. N. et al. Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells // J. Clin. Invest. / R. S. AhimaAmerican Society for Clinical Investigation, 1991. — ISSN 0021-9738; 1558-8238doi:10.1172/JCI115403PMID:1715889
  22. Lalor P., Adams D. CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow // American Journal of Physiology: Gastrointestinal and Liver PhysiologyAmerican Physiological Society, 2008. — ISSN 0193-1857; 1522-1547doi:10.1152/AJPGI.00266.2007PMID:18308860
  23. 23,0 23,1 23,2 23,3 R Giri, Y Shen, M Stins et al. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. // American Journal of Physiology: Cell Physiology — 2000. — ISSN 0363-6143; 1522-1563doi:10.1152/AJPCELL.2000.279.6.C1772PMID:11078691
  24. 24,0 24,1 Ma F., Li T., Zhang H. et al. MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1. // Journal of Cardiovascular PharmacologyLippincott Williams & Wilkins, 2016. — ISSN 0160-2446; 1533-4023doi:10.1097/FJC.0000000000000419PMID:27464494
  25. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  26. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар[үзгәртү | вики-текстны үзгәртү]

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)