CCL5

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/CCL5 latin yazuında])
CCL5
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген CCL5[d][1]
Молекулярная функция CCR5 chemokine receptor binding[d][2][3], receptor signaling protein tyrosine kinase activator activity[d][4], chemokine activity[d][5][6][7], protein self-association[d][4], CCR4 chemokine receptor binding[d][8][3], phosphatidylinositol phospholipase C activity[d][9], protein kinase activity[d][9], cytokine activity[d][3], CCR1 chemokine receptor binding[d][8][10][9][…], phospholipase activator activity[d][9], chemokine receptor binding[d][2][11], гомодимеризация белка[d][4], chemokine receptor antagonist activity[d][12], связывание с белками плазмы[d][13][14][15], chemoattractant activity[d][16], связывание похожих белков[d][14][15][17][…], chemokine activity[d][18][3][19][…] һәм CCR chemokine receptor binding[d][20]
Күзәнәк компоненты Цитоплазма[3], внеклеточная область[d][3][3][3] һәм внеклеточное пространство[d][3][3][3][…]
Биологический процесс leukocyte cell-cell adhesion[d][21], positive regulation of cell-cell adhesion mediated by integrin[d][21], regulation of T cell activation[d][4], positive regulation of smooth muscle cell migration[d][22], activation of phospholipase D activity[d][23], negative regulation of viral genome replication[d][24], positive regulation of ERK1 and ERK2 cascade[d][20], positive regulation of innate immune response[d][25], cellular response to interferon-gamma[d][26], positive regulation of macrophage chemotaxis[d][27], calcium ion transport[d][9], Экзоцитоз[d][9], positive regulation of calcium ion transport[d][13], response to cytokine[d][3], regulation of insulin secretion[d][28], chemokine-mediated signaling pathway[d][29][6][30], positive regulation of cellular biosynthetic process[d][31], response to virus[d][4][3], positive regulation of monocyte chemotaxis[d][3][32][19], cellular response to fibroblast growth factor stimulus[d][33], neutrophil chemotaxis[d][20], response to tumor necrosis factor[d][3], negative regulation of T cell apoptotic process[d][4], positive regulation of GTPase activity[d][20], negative regulation of macrophage apoptotic process[d][3], positive regulation of T cell proliferation[d][34], positive regulation of phosphorylation[d][31], воспалительная реакция[d][6][6][6][…], positive regulation of translational initiation[d][31], response to toxic substance[d][35], positive regulation of epithelial cell proliferation[d][3], positive regulation of tyrosine phosphorylation of STAT protein[d][8], cellular response to organic cyclic compound[d][36], cellular calcium ion homeostasis[d][9], protein tetramerization[d][4], хемотаксис[d][37][3], positive regulation of homotypic cell-cell adhesion[d][4], cellular response to interleukin-1[d][26], иммунный ответ[d][3], positive regulation of viral genome replication[d][4], positive regulation of receptor signaling pathway via JAK-STAT[d][38], lipopolysaccharide-mediated signaling pathway[d][36], positive regulation of T cell migration[d][39], regulation of chronic inflammatory response[d][4], positive regulation of smooth muscle cell proliferation[d][22], neutrophil activation[d][4], protein kinase B signaling[d][36], positive regulation of cell migration[d][40], positive regulation of natural killer cell chemotaxis[d][40], передача сигнала между клетками[d][21], eosinophil chemotaxis[d][27], dendritic cell chemotaxis[d][31], MAPK cascade[d][36], macrophage chemotaxis[d][31], positive regulation of T cell chemotaxis[d][7][29][41][…], regulation of neuron death[d][42], positive regulation of phosphatidylinositol 3-kinase signaling[d][43], negative regulation of G protein-coupled receptor signaling pathway[d][9], positive regulation of T cell apoptotic process[d][4], positive regulation of cell adhesion[d][44], negative regulation of chemokine-mediated signaling pathway[d][3], monocyte chemotaxis[d][45], positive chemotaxis[d][3], positive regulation of protein tyrosine kinase activity[d][3], cellular response to tumor necrosis factor[d][26], positive regulation of activation of Janus kinase activity[d][38], regulation of signaling receptor activity[d][3], G protein-coupled receptor signaling pathway[d][6][46][30], cytokine-mediated signaling pathway[d][3], monocyte chemotaxis[d][10][20], воспалительная реакция[d][3][3][3][…], G protein-coupled receptor signaling pathway[d][3][28][42][…], positive regulation of T cell chemotaxis[d][27][31][19][…], lymphocyte chemotaxis[d][20], chemokine-mediated signaling pathway[d][31][3][42][…], cellular response to interferon-gamma[d][33][20], cellular response to interleukin-1[d][33][20], cellular response to tumor necrosis factor[d][33][20] һәм positive regulation of monocyte chemotaxis[d][19][32]
Изображение Gene Atlas

CCL5 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[47][48]

Искәрмәләр[үзгәртү | вики-текстны үзгәртү]

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 Nibbs R. J., Graham G. J. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — 10 p. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.19.12495 — PMID:9139699
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 3,17 3,18 3,19 3,20 3,21 3,22 3,23 3,24 3,25 3,26 3,27 3,28 GOA
  4. ↑ 4,00 4,01 4,02 4,03 4,04 4,05 4,06 4,07 4,08 4,09 4,10 4,11 V Appay, A Brown, S Cribbes et al. Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1999. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.274.39.27505 — PMID:10488085
  5. ↑ Schröder J. M., Y Kameyoshi, E Christophers Platelets secrete an eosinophil-chemotactic cytokine which is a member of the C-C-chemokine family // Advances in Experimental Medicine and Biology — Springer Nature, 1993. — ISSN 0065-2598; 2214-8019 — doi:10.1007/978-1-4615-2952-1_13 — PMID:7524281
  6. ↑ 6,0 6,1 6,2 6,3 6,4 6,5 GOA
  7. ↑ 7,0 7,1 Schall T. J., K Bacon, Toy K. J. et al. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES // Nature / M. Skipper — NPG, Springer Science+Business Media, 1990. — ISSN 1476-4687; 0028-0836 — doi:10.1038/347669A0 — PMID:1699135
  8. ↑ 8,0 8,1 8,2 M Wong, Fish E. N. RANTES and MIP-1alpha activate stats in T cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.1.309 — PMID:9417081
  9. ↑ 9,0 9,1 9,2 9,3 9,4 9,5 9,6 9,7 Richardson R. M., Pridgen B. C., B Haribabu et al. Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.275.13.9201 — PMID:10734056
  10. ↑ 10,0 10,1 Berkhout T. A., J Gohil, P Gonzalez et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1) // Biochem. Pharmacol. — Elsevier BV, 2000. — ISSN 0006-2952; 1873-2968 — doi:10.1016/S0006-2952(99)00354-8 — PMID:10660125
  11. ↑ K Neote, Mak J. Y., Kolakowski L. F. et al. Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor // Blood — American Society of Hematology, Elsevier BV, 1994. — ISSN 0006-4971; 1528-0020 — PMID:7517217
  12. ↑ Uguccioni M. RANTES and MCP-3 antagonists bind multiple chemokine receptors // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1996. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.271.18.10521 — PMID:8631850
  13. ↑ 13,0 13,1 C Combadiere, Ahuja S. K., Tiffany H. L. et al. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 1996. — ISSN 0741-5400; 1938-3673 — doi:10.1002/JLB.60.1.147 — PMID:8699119
  14. ↑ 14,0 14,1 Scherf T. NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains // FEBS J. — Wiley-Blackwell, 2013. — ISSN 1742-464X; 0014-2956; 1742-4658; 1432-1033 — doi:10.1111/FEBS.12230 — PMID:23480650
  15. ↑ 15,0 15,1 Hundelshausen P. V., Grommes J., Weber C. et al. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation // Sci. Transl. Med. — AAAS, 2017. — ISSN 1946-6234; 1946-6242 — doi:10.1126/SCITRANSLMED.AAH6650 — PMID:28381538
  16. ↑ Ko J., Jang S., Kim Y. S. et al. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines // FASEB J. — FASEB, 2004. — ISSN 0892-6638; 1530-6860 — doi:10.1096/FJ.03-0867FJE — PMID:15001559
  17. ↑ Wang X., Watson C., Sharp J. S. et al. Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data // Structure / C. D. Lima — Cell Press, Elsevier BV, 2011. — ISSN 0969-2126; 1878-4186 — doi:10.1016/J.STR.2011.06.001 — PMID:21827949
  18. ↑ Schröder J. M., Y Kameyoshi, E Christophers Platelets secrete an eosinophil-chemotactic cytokine which is a member of the C-C-chemokine family // Advances in Experimental Medicine and Biology — Springer Nature, 1993. — ISSN 0065-2598; 2214-8019 — doi:10.1007/978-1-4615-2952-1_13 — PMID:7524281
  19. ↑ 19,0 19,1 19,2 19,3 Schall T. J., K Bacon, Toy K. J. et al. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES // Nature / M. Skipper — NPG, Springer Science+Business Media, 1990. — ISSN 1476-4687; 0028-0836 — doi:10.1038/347669A0 — PMID:1699135
  20. ↑ 20,0 20,1 20,2 20,3 20,4 20,5 20,6 20,7 20,8 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  21. ↑ 21,0 21,1 21,2 Lloyd A. R., Oppenheim J. J., Kelvin D. J. et al. Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins // J. Immunol. — Baltimore: 1996. — ISSN 0022-1767; 1550-6606 — PMID:8558019
  22. ↑ 22,0 22,1 Kuo P., Hsu Y., Huang M. et al. Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling // Toxicol. Sci. — Orlando, FL, Cary, NC, San Diego, CA, Oxford, England: Oxford University Press, Academic Press, 2011. — ISSN 1096-6080; 1096-0929 — doi:10.1093/TOXSCI/KFR030 — PMID:21297082
  23. ↑ KB B., TJ S., DJ D. RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA // J. Immunol. — Baltimore: 1998. — ISSN 0022-1767; 1550-6606 — PMID:9469451
  24. ↑ BR L., DM M., NL W. et al. TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression // J. Immunol. — Baltimore: 1999. — ISSN 0022-1767; 1550-6606 — PMID:10490959
  25. ↑ Fox J. M., Letellier E., Oliphant C. J. et al. TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes // Blood — American Society of Hematology, Elsevier BV, 2011. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2010-05-287474 — PMID:21148810
  26. ↑ 26,0 26,1 26,2 Radeke H. H. Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells // Kidney Int. — NPG, Elsevier BV, 1997. — ISSN 0085-2538; 1523-1755 — doi:10.1038/KI.1997.482 — PMID:9407497
  27. ↑ 27,0 27,1 27,2 Zerwes H. CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo // J. Invest. Dermatol. / M. C. Udey — NPG, Elsevier BV, 2006. — ISSN 0022-202X; 1523-1747 — doi:10.1038/SJ.JID.5700369 — PMID:16778803
  28. ↑ 28,0 28,1 King A. J., Jones P. M., Persaud S. J. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis // Diabetologia — Springer Science+Business Media, 2013. — ISSN 0012-186X; 1432-0428 — doi:10.1007/S00125-013-3022-X — PMID:23979485
  29. ↑ 29,0 29,1 Murooka T. T., Fish E. N. CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1 // Blood — American Society of Hematology, Elsevier BV, 2008. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2007-11-125039 — PMID:18337562
  30. ↑ 30,0 30,1 Schaller H. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 // Br. J. Pharmacol. — Wiley-Blackwell, 2006. — ISSN 0007-1188; 1476-5381 — doi:10.1038/SJ.BJP.0706909 — PMID:17001303
  31. ↑ 31,0 31,1 31,2 31,3 31,4 31,5 31,6 Murooka T. T., Fish E. N. CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1 // Blood — American Society of Hematology, Elsevier BV, 2008. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2007-11-125039 — PMID:18337562
  32. ↑ 32,0 32,1 Läubli H., Spanaus K., Borsig L. Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes // Blood — American Society of Hematology, Elsevier BV, 2009. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2008-10-186585 — PMID:19779041
  33. ↑ 33,0 33,1 33,2 33,3 Radeke H. H. Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells // Kidney Int. — NPG, Elsevier BV, 1997. — ISSN 0085-2538; 1523-1755 — doi:10.1038/KI.1997.482 — PMID:9407497
  34. ↑ Nguyen K. D., Fohner A., Booker J. D. et al. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma // J. Immunol. — Baltimore: 2008. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.181.8.5386 — PMID:18832695
  35. ↑ Kanki P. J., Essex M. E. In vitro correlates of HIV-2-mediated HIV-1 protection // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2000. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.97.12.6797 — PMID:10841574
  36. ↑ 36,0 36,1 36,2 36,3 Wu F., Zhang W., Li L. et al. Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells // Eur. J. Pharmacol. — Elsevier BV, 2011. — ISSN 0014-2999; 1879-0712; 0922-4106 — doi:10.1016/J.EJPHAR.2010.11.022 — PMID:21147091
  37. ↑ Y. Kameyoshi, A. Dörschner, Mallet A. I. et al. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils // J. Exp. Med. — Rockefeller University Press, 1992. — ISSN 0022-1007; 1540-9538 — doi:10.1084/JEM.176.2.587 — PMID:1380064
  38. ↑ 38,0 38,1 M Wong, S Uddin, B Majchrzak et al. Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M010750200 — PMID:11278738
  39. ↑ Chiang Y., Lee F. S. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration // PLOS ONE / PLOS ONE Editors — PLoS, 2013. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0061761 — PMID:23620790
  40. ↑ 40,0 40,1 A Ben-Baruch, L Xu, Young P. R. et al. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.38.22123 — PMID:7545673
  41. ↑ Zerwes H. CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo // J. Invest. Dermatol. / M. C. Udey — NPG, Elsevier BV, 2006. — ISSN 0022-202X; 1523-1747 — doi:10.1038/SJ.JID.5700369 — PMID:16778803
  42. ↑ 42,0 42,1 42,2 Schaller H. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 // Br. J. Pharmacol. — Wiley-Blackwell, 2006. — ISSN 0007-1188; 1476-5381 — doi:10.1038/SJ.BJP.0706909 — PMID:17001303
  43. ↑ Turner L, SG W., Westwick J RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase // J. Immunol. — Baltimore: 1995. — ISSN 0022-1767; 1550-6606 — PMID:7544376
  44. ↑ OM H., HF D., AK S. et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 // Blood — American Society of Hematology, Elsevier BV, 2000. — ISSN 0006-4971; 1528-0020 — PMID:10910894
  45. ↑ Berkhout T. A., J Gohil, P Gonzalez et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1) // Biochem. Pharmacol. — Elsevier BV, 2000. — ISSN 0006-2952; 1873-2968 — doi:10.1016/S0006-2952(99)00354-8 — PMID:10660125
  46. ↑ King A. J., Jones P. M., Persaud S. J. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis // Diabetologia — Springer Science+Business Media, 2013. — ISSN 0012-186X; 1432-0428 — doi:10.1007/S00125-013-3022-X — PMID:23979485
  47. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  48. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар[үзгәртү | вики-текстны үзгәртү]

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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