Эчтәлеккә күчү

HPSE

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/HPSE latin yazuında])
HPSE
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген HPSE[d][1]
Молекуляр функция protein dimerization activity[d][2], heparanase activity[d][3][4], beta-glucuronidase activity[d][5], hydrolase activity, acting on glycosyl bonds[d][6], связывание с белками плазмы[d][7][8][9], syndecan binding[d][7], гидролазная активность[d][6] һәм heparanase activity[d][10]
Күзәнәк компоненты intracellular membrane-bounded organelle[d][6], мембрана[d][6][6], нуклеоплазма[d][6], lysosomal membrane[d][6], lysosomal lumen[d][6], липидный рафт[d][6], лизосома[6][11], төш[6][6][12], күзәнәк тышындагы өлкә[d][6][6], specific granule lumen[d][6] һәм внеклеточный матрикс[d][13]
Биологик процесс positive regulation of osteoblast proliferation[d][6][12], позитивная регуляция сигналов от протеинкиназы В[d][6][14], heparan sulfate proteoglycan catabolic process[d][10], regulation of hair follicle development[d][15], positive regulation of hair follicle development[d][6], Заживление ран[d][6], vascular wound healing[d][6], агрегация клеток[d][6], positive regulation of blood coagulation[d][8], proteoglycan metabolic process[d][16], glycosaminoglycan catabolic process[d][6], positive regulation of vascular endothelial growth factor production[d][17], cell-matrix adhesion[d][18], angiogenesis involved in wound healing[d][6][13], neutrophil degranulation[d][6] һәм cell-matrix adhesion[d][19][13]
Изображение Gene Atlas

HPSE (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[20][21]

  1. 1,0 1,1 UniProt
  2. Vlodavsky I., Levy-Adam F., Ilan N. Heterodimer formation is essential for heparanase enzymatic activity // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 2003. — ISSN 0006-291X; 1090-2104doi:10.1016/S0006-291X(03)01478-5PMID:12927802
  3. GOA
  4. Okada Y., Yamada S., Toyoshima M. et al. Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M206510200PMID:12213822
  5. I Vlodavsky, Y Friedmann, M Elkin et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis // Nat. Med.NPG, Springer Science+Business Media, 1999. — ISSN 1078-8956; 1546-170Xdoi:10.1038/10518PMID:10395325
  6. 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 6,10 6,11 6,12 6,13 6,14 6,15 6,16 6,17 6,18 6,19 6,20 6,21 6,22 6,23 GOA
  7. 7,0 7,1 Vlodavsky I., Levy-Adam F., Ilan N. et al. Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M402131200PMID:15292202
  8. 8,0 8,1 Vlodavsky I., Brenner B. Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII // HaematologicaFerrata Storti Foundation, 2010. — ISSN 0390-6078; 1592-8721; 1138-0381doi:10.3324/HAEMATOL.2010.023713PMID:20634491
  9. Poon I., Hulett M. D. Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions // Int. J. Biochem. Cell Biol.Elsevier BV, 2010. — ISSN 1357-2725; 0020-711X; 1878-5875doi:10.1016/J.BIOCEL.2010.05.008PMID:20561914
  10. 10,0 10,1 Okada Y., Yamada S., Toyoshima M. et al. Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M206510200PMID:12213822
  11. Vlodavsky I., Levy-Adam F., Ilan N. et al. Processing and activation of latent heparanase occurs in lysosomes // J. Cell Sci.The Company of Biologists, 2004. — ISSN 0021-9533; 1477-9137doi:10.1242/JCS.01068PMID:15126626
  12. 12,0 12,1 Yu D., Li R. W. Heparanase in primary human osteoblasts // J. Orthop. Res.Wiley, 2010. — ISSN 0736-0266; 1554-527Xdoi:10.1002/JOR.21138PMID:20309870
  13. 13,0 13,1 13,2 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  14. Vlodavsky I., Ilan N., Gingis-Velitski S. et al. Heparanase induces endothelial cell migration via protein kinase B/Akt activation // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M400554200PMID:15044433
  15. Malgouries S., Donovan M., Thibaut S. et al. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis // Experimental DermatologyWiley-Blackwell, 2008. — ISSN 0906-6705; 1600-0625doi:10.1111/J.1600-0625.2008.00739.XPMID:18557927
  16. M Toyoshima, M Nakajima Human heparanase. Purification, characterization, cloning, and expression // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1999. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.274.34.24153PMID:10446189
  17. Vlodavsky I., Levy-Adam F., Ilan N. et al. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation // Cancer Res. / G. C. PrendergastAmerican Association for Cancer Research, 2006. — ISSN 0008-5472; 1538-7445doi:10.1158/0008-5472.CAN-05-1811PMID:16452201
  18. Vlodavsky I. Heparanase mediates cell adhesion independent of its enzymatic activity // FASEB J.FASEB, 2003. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.02-0773COMPMID:12773484
  19. Vlodavsky I. Heparanase mediates cell adhesion independent of its enzymatic activity // FASEB J.FASEB, 2003. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.02-0773COMPMID:12773484
  20. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  21. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)