NF1

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NF1
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген Нейрофибромин[d][1]
Молекулярная функция phosphatidylcholine binding[d][2], связывание с белками плазмы[d][3][4][5], phosphatidylethanolamine binding[d][2], lipid binding[d][6] һәм GTPase activator activity[d][6][6][7][…]
Күзәнәк компоненты цитозоль[d][6], мембрана[d][8], intrinsic component of the cytoplasmic side of the plasma membrane[d][9], ядрышко[d][6], аксон[d][10], дендрит[d][10], пресинапс[d][6], Цитоплазма[11][9][9], Төш[10][6], Цитоплазма[10][6] һәм мембрана[d][12]
Биологический процесс cellular response to heat[d][6], regulation of angiogenesis[d][13][6], negative regulation of cell-matrix adhesion[d][6], positive regulation of extrinsic apoptotic signaling pathway in absence of ligand[d][6], Имитационное научение[d][6], негативная регуляция пролиферации клеток[d][6], negative regulation of astrocyte differentiation[d][6], regulation of long-term neuronal synaptic plasticity[d][6], regulation of MAPK cascade[d][6], regulation of GTPase activity[d][14][6], glutamate secretion, neurotransmission[d][6], развитие миндалевидного тела[d][6], negative regulation of Rac protein signal transduction[d][6], развитие нервной трубки[d][6], Танып-белү[15], negative regulation of cell migration[d][16][6], regulation of gene expression[d][6], positive regulation of extrinsic apoptotic signaling pathway via death domain receptors[d][6], negative regulation of neurotransmitter secretion[d][6], positive regulation of endothelial cell proliferation[d][6], gamma-aminobutyric acid secretion, neurotransmission[d][6], negative regulation of osteoclast differentiation[d][6], negative regulation of endothelial cell proliferation[d][16][13][6], regulation of blood vessel endothelial cell migration[d][13], regulation of cell population proliferation[d][6], regulation of long-term synaptic potentiation[d][6], negative regulation of angiogenesis[d][6], skeletal muscle tissue development[d][6], regulation of synaptic transmission, GABAergic[d][6], extrinsic apoptotic signaling pathway via death domain receptors[d][6], передача сигнала[d][6], positive regulation of GTPase activity[d][6][16][6][…], Schwann cell development[d][6][6], развитие надпочечников[d][6][6], развитие спинного мозга[d][6][6], MAPK cascade[d][6][6][6], phosphatidylinositol 3-kinase signaling[d][6][6], развитие сердца[d][6][6], positive regulation of neuron apoptotic process[d][6][6], развитие периферической нервной системы[d][6][6], Заживление ран[d][6][6], развитие симпатической нервной системы[d][6][6], osteoblast differentiation[d][6][6], positive regulation of apoptotic process[d][6][6], negative regulation of fibroblast proliferation[d][6][6], forebrain astrocyte development[d][6][6], metanephros development[d][6][6], negative regulation of MAP kinase activity[d][6][6], пигментация[d][6][6], развитие печени[d][6][6], визуальное обучение[d][6][6], regulation of glial cell differentiation[d][6][6], artery morphogenesis[d][6][6], positive regulation of adenylate cyclase activity[d][6][6], negative regulation of Ras protein signal transduction[d][9][9], regulation of bone resorption[d][6][6], extracellular matrix organization[d][6][6], actin cytoskeleton organization[d][6][6], cerebral cortex development[d][6][6], negative regulation of protein kinase activity[d][6][6], Ras protein signal transduction[d][6][6], forebrain morphogenesis[d][6][6], negative regulation of oligodendrocyte differentiation[d][6][6], regulation of cell-matrix adhesion[d][6][6], smooth muscle tissue development[d][6][6], развитие мозга[d][6][6], collagen fibril organization[d][6][6], myelination in peripheral nervous system[d][6][6], camera-type eye morphogenesis[d][6][6], cell communication[d][6][6], response to hypoxia[d][6][6], negative regulation of neuroblast proliferation[d][6][6], negative regulation of MAPK cascade[d][6][16][6], hair follicle maturation[d][6], negative regulation of protein import into nucleus[d][6] һәм negative regulation of Ras protein signal transduction[d][6]

NF1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]

Искәрмәләр[үзгәртү | вики-текстны үзгәртү]

  1. 1,0 1,1 UniProt
  2. 2,0 2,1 Scheffzek K., Welti S., Wilm M. The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex // Journal of Molecular Biology / P. WrightElsevier BV, 2007. — ISSN 0022-2836; 1089-8638doi:10.1016/J.JMB.2006.11.055PMID:17187824
  3. Chaumont-Dubel S., Sévéno M., Fone K. et al. 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia // EMBO Molecular Medicine / P. SansonettiWiley, 2012. — ISSN 1757-4676; 1757-4684doi:10.1002/EMMM.201201410PMID:23027611
  4. Messiaen L. Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes // J. Invest. Dermatol. / M. C. UdeyNPG, Elsevier BV, 2006. — ISSN 0022-202X; 1523-1747doi:10.1038/SJ.JID.5700087PMID:16374483
  5. Hsueh Y. P., Roberts A. M., M Volta et al. Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans // J. Neurosci. / M. PicciottoSociety for Neuroscience, 2001. — ISSN 0270-6474; 1529-2401doi:10.1523/JNEUROSCI.21-11-03764.2001PMID:11356864
  6. 6,000 6,001 6,002 6,003 6,004 6,005 6,006 6,007 6,008 6,009 6,010 6,011 6,012 6,013 6,014 6,015 6,016 6,017 6,018 6,019 6,020 6,021 6,022 6,023 6,024 6,025 6,026 6,027 6,028 6,029 6,030 6,031 6,032 6,033 6,034 6,035 6,036 6,037 6,038 6,039 6,040 6,041 6,042 6,043 6,044 6,045 6,046 6,047 6,048 6,049 6,050 6,051 6,052 6,053 6,054 6,055 6,056 6,057 6,058 6,059 6,060 6,061 6,062 6,063 6,064 6,065 6,066 6,067 6,068 6,069 6,070 6,071 6,072 6,073 6,074 6,075 6,076 6,077 6,078 6,079 6,080 6,081 6,082 6,083 6,084 6,085 6,086 6,087 6,088 6,089 6,090 6,091 6,092 6,093 6,094 6,095 6,096 6,097 6,098 6,099 6,100 6,101 6,102 6,103 6,104 6,105 6,106 6,107 6,108 6,109 6,110 6,111 6,112 6,113 6,114 6,115 6,116 6,117 6,118 6,119 6,120 6,121 6,122 GOA
  7. Collins F., Marchuk D. A. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins // CellCell Press, Elsevier BV, 1990. — ISSN 0092-8674; 1097-4172doi:10.1016/0092-8674(90)90151-4PMID:2121371
  8. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  9. 9,0 9,1 9,2 9,3 9,4 GOA
  10. 10,0 10,1 10,2 10,3 Daston M. M., H Scrable, M Nordlund et al. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes // Neuron / K. BroseCell Press, Elsevier BV, 1992. — ISSN 0896-6273; 1097-4199doi:10.1016/0896-6273(92)90270-NPMID:1550670
  11. Daston M. M., H Scrable, M Nordlund et al. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes // Neuron / K. BroseCell Press, Elsevier BV, 1992. — ISSN 0896-6273; 1097-4199doi:10.1016/0896-6273(92)90270-NPMID:1550670
  12. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  13. 13,0 13,1 13,2 Thomas S. L., George H De Vries Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells // Neurochem. Res.Springer Science+Business Media, 2007. — ISSN 0364-3190; 1573-6903doi:10.1007/S11064-007-9279-ZPMID:17404841
  14. Collins F., J Downward Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients // Nature / M. SkipperNPG, Springer Science+Business Media, 1992. — ISSN 1476-4687; 0028-0836doi:10.1038/356713A0PMID:1570015
  15. Gill D. S., Shores E. A., North K. N. T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning // Journal of Neurology, Neurosurgery and PsychiatryBMJ, 2007. — ISSN 0022-3050; 1468-330Xdoi:10.1136/JNNP.2006.108134PMID:17299016
  16. 16,0 16,1 16,2 16,3 Munchhof A. M. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells // Human Molecular GeneticsOUP, 2006. — ISSN 0964-6906; 1460-2083doi:10.1093/HMG/DDL108PMID:16648142
  17. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  18. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар[үзгәртү | вики-текстны үзгәртү]

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)